CCAAT增强子结合蛋白A（CEBPA）是调节血液发育过程中髓系分化和造血干祖细胞活性的关键转录因子之一。CEBPA基因突变常见于急性髓系白血病（AML）中，最近研究表明CEBPA bZIP框内单位点和经典双等位基因突变AML患者均具有类似的临床特征，已被单独划分为AML亚群。CEBPA bZIP框内突变而非传统的双等位CEBPA基因突变成为AML良好预后的分子指标，表明其在AML疾病进展和治疗预后中的重要性和特殊性。本文将从CEBPA蛋白在血液系统中的功能、CEBPA bZIP框内突变AML的临床特征与分子作用机制、以及伴CEBPA突变AML的治疗现状等方面进行综述，为进一步研究CEBPA bZIP框内突变在AML中的致病性和精准治疗新药物开发提供参考。

   CAAT enhancer-binding protein A（CEBPA）is one of the  key transcription factors  regulating myeloid differentiation and hematopoietic stem/progenitor cell maintenance during hematopoiesis．CEBPA gene mutations are commonly found in acute myeloid leukemia（AML）．Recent studies have demonstrated that AML patients haboring single CEBPA bZIP in-frame mutations or classical bi-allelic CEBPA mutations show similar clinical features and it has been individually classified as AML subgroup．Additionally，it is CEBPA bZIP in-frame mutations rather than the traditional biallelic CEBPA mutations that have emerged as a molecular indicator of favorable prognosis for clinical AML management，suggesting its importance and specificity in AML disease progression and therapeutic prognosis．Here，we reviewed serval aspects including the hematopoietic function of CEBPA protein，the clinical features and molecular mechanisms of AML with CEBPA bZIP in-frame mutations，and the current status of the treatment of AML with CEBPA mutations，which will provide a reference for further study of the pathogenicity of CEBPA bZIP in-frame mutations in AML and the development of new drugs for precision therapy．

       药源性心脏毒性是临床常见的药物不良反应，是药物研发和临床治疗需面临的严峻考验。对药源性心脏毒性的评价是目前研究的重点，基于其机制复杂多样、临床表现不一、影响因素多，早期评价具有困难。生物标志物是评价心脏毒性的重要指标之一，文章总结了目前已经报道的多种心脏毒性标志物及其潜在的生物标志物，希望能从中找到特异性强、敏感性高的标志物，以贡献于药物心脏安全性评价工作。

    As a common clinical adverse reaction，pharmacogenic cardiotoxicity is a severe challenge for drug development and clinical treatment．The evaluation of pharmacogenic cardiotoxicity is the focus of current research，and early evaluation is difficult with its complex and diverse mechanisms，varying clinical manifestations，and numerous influencing factors．Biomarker is an important index to evaluate cardiotoxicity．This article summarizes a variety of cardiotoxicity biomarkers and other potential biomarkers that have been reported so far，hoping to find  biomarkers with strong specificity and high sensitivity，so as tocontribute to the evaluation on cardiac safety of drugs．

       近几十年来，全球近视患病率不断上升，已成为全世界主要的公共卫生问题之一。众多研究表明户外活动能有效控制近视的发生和发展。本文综述了户外活动对近视防控作用的研究进展及其作用机制，以期为近视防控提供新的思路。

     In recent decades, the prevalence of myopia has been increasing globally, becoming one of the major public health issues worldwide. Numerous studies indicate that outdoor activities can effectively control the onset and progression of myopia. This article reviews the research progress on prevention and control effect and mechanism of outdoor activities on myopia, hoping to provide new insights for myopia prevention and control.