目的 探讨Yes1相关蛋白（YAP）及p65在弥漫大B细胞淋巴瘤（DLBCL）中与临床特征的相关性及对DLBCL治疗和预后的意义。方法 收集65例DLBCL和10例反应性增生淋巴结患者组织进行免疫组织化学染色,分析两组差异;对多种临床特征与YAP、p65的相关性进行统计学和生存差异性分析。结果 YAP、p65染色评分在两组间比较差异有统计学意义（P<0.05）;YAP评分与疗效分组呈正相关,与治疗前乳酸脱氢酶（LDH）、Ann-Arbor分期、国际预后指数（IPI）呈负相关（P<0.05）;p65表达与疗效分组呈负相关,与治疗前LDH水平、Ann-Arbor分组、美国东部肿瘤协作组活动状态评分（ECOG）ECOG分组、结外侵犯、IPI评分、巨大包块呈正相关（P<0.05）。IPI及p65评分是DLBCL患者总生存期（OS）的独立危险因素（P<0.05）。共表达分层中YAP-/p65⁺组患者OS均值最低。结论 对于DLBCL,YAP低表达或p65高表达提示患者瘤荷较大、较差的疗效和预后。

Objective To investigate the correlation of YAP and p65 with clinical features in diffuse large B-cell lymphoma（DLBCL）and the significance for treatment and prognosis．Methods Tissues from 65 patients with DLBCL and 10 patients with reactive hyperplasia lymph node were collected for immunohistochemistry staining to analyze the differences between the two groups;statistical analysis and survival difference analysis of the correlation between various clinical features and YAP,p65 were performed．Results YAP and p65 staining scores were significantly different between the two groups（P<0.05）．YAP scores were positively correlated with efficacy subgroups,and negatively correlated with LDH levels before treatment,Ann-Arbor staging,and International Prognostic Index（IPI）scores before treatment（P<0.05）;p65 expression was negatively correlated with efficacy subgroups,and positively correlated with pretreatment LDH levels,Ann-Arbor subgroup,ECOG subgroup,extra-nodal invasion,IPI scores,and huge mass（P<0.05）．IPI and p65 score were independent prognostic risk factors for overall survival（OS） in DLBCL patients（P<0.05）．The mean value of OS was the lowest in patients in the YAP-/p65⁺ group in the co-expression stratification．Conclusions Low expression of YAP or high expression of p65 suggests larger tumor load and poorer outcome and prognosis in patients for DLBCL．

目的 观察自体巩膜倒扣包裹羟基磷灰石(HA)义眼台一期植入术临床效果、术后并发症及随访预后情况。方法 选取我院2012年7月—2014年3月期间26例需植入HA义眼台患者,采用进口材料HA义眼台,直径18~22 mm,重量约2 g,施行眼球摘除术后,予眼内容剜除,自体巩膜壳倒扣包裹于HA义眼台前端,一期植入肌锥的方法。结果 随访2～20个月,2例发生结膜充血水肿(7.69%),3例发生结膜创口愈合不良(11.54%),行保守治疗或于手术室清创缝合后痊愈,余未发生义眼台排斥、暴露、感染、移位及眼球假体固定。结论 羟基磷灰石(HA)义眼台具有高度的生物相容性,无毒性、无抗原性,纤维结缔组织可长入内联多孔,不引起明显异物排斥反应,是目前较理想的眼座材料。自体巩膜倒扣包裹HA的应用减少了义眼台植入术后并发症的产生,术后眼窝饱满,眼球假体活动度可,外观恢复满意,临床效果好,是眼眶整形术中较为理想的方法。