目的 通过波幅整合脑电图(aEEG)长程监测评估胆红素水平(TSB)、脑干听觉诱发电位(BAEP)及脑电图(EEG)异常程度对足月新生儿睡眠结构的影响。方法 对159例高胆红素血症足月新生儿行12小时床边监测长程脑电图,计算aEEG上睡眠-觉醒周期(SWC)安静睡眠(QS)时间长度比例、收集当日的TSB、BAEP及EEG结果。结果 在159例病人中,数据可视化结果显示随着胆红素水平的升高、EEG及BAEP异常程度的增加,QS期的比例逐渐减少。逐步广义线性模型结果证实胆红素水平及EEG异常是导致安静睡眠比例减少的主要因素,而BAEP异常程度则不显著。结论 随着胆红素水平的增高及脑电图异常率的增加,足月新生儿睡眠-觉醒周期安静睡眠比例逐渐减少,SWC结构发生改变。

Objective To investigate the impacts of total serum bilirubin level (TSB), EEG and BAEP abnormalities to full term neonates' sleep-wake cycles' (SWC) structure through the amplitude-integrated electroencephalography (aEEG). Methods Quiet sleep (QS) ratio of SWC within 12 hours of 159 neonates with hyperbilirubinermia were obtained from the aEEG traces, total serum bilirubin (TSB) level, EEG and BAEP results of the recording day were also recorded. Results QS ratio of SWC decreased along with the elevated TSB level, EEG and BAEP abnormality in 159 cases. Furthermore stepwise generalized linear regression model comfirmed the TSB level, EEG abnormalities were the key factors for the reduced QS ratio while the BAEP was no statistically significant. Conclusion Full term neonates' SWC showed a constructive change by means of QS ratio reduction according to the elevating TSB level and EEG abnormality.