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《广州医药》编辑部
目的 探讨基于思维导图的绿色通道急救干预对急性心肌梗死患者介入治疗的效果。方法 对天津市人民医院2022年1月—2024年12月收治的80例AMI患者进行研究,依照收治时间进行分组,将2022年1月—2023年6月采取常规急救流程干预的40例患者分为常规组,将2023年7月—2024年12月的采取基于思维导图的绿色通道急救干预的40例患者分为思维导图组。比较两组患者急救效率、急救前后生命体征(心率、舒张压、收缩压)、心肌损伤指标[磷酸肌酸激酶(CK-MB)及肌钙蛋白Ⅰ(cTnI)],最后比较两组患者干预满意度。结果 对比急救效率发现,思维导图组的预检时间、会诊时间、导管室激活时间、急诊送至PCI手术时间均短于常规组(P<0.05);对比急救前后生命体征发现,与急救前对比,急救后两组的心率、舒张压、收缩压均降低(P<0.05),急救前后两组心率、舒张压、收缩压比较差异无统计学意义(P>0.05);对比急救前后心肌损伤指标发现,急救前两组CK-MB、cTnI比较差异无统计学意义(P>0.05),急救后,思维导图组CK-MB、cTnI低于常规组与急救前(P<0.05);对比干预满意度发现,思维导图组干预满意度为100.00%,高于常规组的85.00%(P<0.05)。结论 基于思维导图的绿色通道急救干预可提升AMI患者的急救效率,稳定患者生命体征,减轻心肌损伤的同时,提升患者干预满意度。
Objective To explore the effect of green channel emergency nursing based on mind mapping on percutaneous coronary intervention(PCI) of patients with acute myocardial infarction(AMI).Methods A study was conducted on 80 AMI patients admitted to Tianjin People’s Hospital from January 2022 to December 2024.The patients were divided into two groups based on their admission time.The 40 patients who received routine emergency nursing interventions from January 2021 to June 2023 were assigned to the conventional group,while the 40 patients who received green channel emergency nursing based on mind mapping from July 2023 to November 2024 were assigned to the mind mapping group.The emergency treatment efficacy,vital signs(heart rate,diastolic blood pressure,systolic bloodpressure),myocardial injury indicators(phosphocreatine kinase[CK-MB],and troponin I[cTn1])between two groups of patients before and after emergency treatment were compared.Results The pre-examination time,consultation time,catheterization room activation time and emergency room to PCI operation time of mind mapping group were all shorter than those of conventional group(P<0.05).Compared with the vital signs before and after emergency treatment,we found that the heart rate,diastolic pressure and systolic blood pressure of the two groups decreased after emergency treatment(P<0.05),and there was no significant difference between the heart rate,diastolic pressure and systolic blood pressure of the two groups before and after emergency treatment(P>0.05).Comparing the myocardial injury indicators before and after emergency treatment,there was no significant difference in CK-MB and cTn1 between the two groups before emergency treatment(P>0.05).After emergency treatment,CK-MB and cTn1 in the mind map group were lower than those in the conventional group and before emergency treatment(P<0.05).Comparing the intervention satisfaction,it was found that the mind mapping group of 100.00% was higher than the conventional group of 85.00%(P<0.05).Conclusions Green channel emergency nursing based on mind mapping can improve the efficiency of emergency treatment for AMI patients,stabilize their vital signs,reduce myocardial injury,improve patient intervention satisfaction.
目的 调查深圳地区综合性医院门诊幽门螺杆菌(Hp)对8种常见抗菌药物的耐药情况。方法 采集13C呼气试验阳性的患者胃黏膜标本313例,进行Hp分离培养及抗菌药物敏感性试验。结果 313例患者分离培养得到247例Hp菌株,培养阳性率78.91%,不同性别、不同年龄患者Hp分离培养阳性率比较差异无统计学意义(P>0.05)。Hp对甲硝唑、克拉霉素、左氧氟沙星、利福平、阿莫西林、四环素、呋喃唑酮、庆大霉素耐药率依次为88.66%(219/247)、38.46%(95/247)、38.06%(94/247)、4.05%(10/247)、1.21%(3/247)、0.40%(1/247)、0.40%(1/247)、0(0/247)。双重耐药率为38.46%(95/247),其中Hp对克拉霉素+甲硝唑组合耐药率最高(18.62%,46/247),对甲硝唑+左氧氟沙星耐药率居其次(17.00%,42/247)。多重耐药率为19.84%(49/247)。不同年龄、性别患者双重耐药率、多重耐药率比较差异均无统计学意义(P>0.05)。结论 深圳地区分离的Hp菌株对甲硝唑、克拉霉素、左氧氟沙星耐药率相对更高,且双重耐药、多重耐药情况严重。
Objective To investigate the antibiotic resistance of Helicobacter pylori(Hp)to eight commonly used antibiotics in outpatients of general hospitals in Shenzhen.Methods Gastric mucosal samples were collected from 313 patients who tested positive for the 13C breath test,and Hp strains were isolated and cultured.Antibiotic susceptibility testing was performed on the isolated Hp strains.Results Of the 313 patients,247 Hp strains were isolated,with a culture-positive rate of 78.91%.There was no significant difference in culture-positive rates between different genders and age groups(P>0.05).The resistance rates to metronidazole,clarithromycin,levofloxacin,rifampicin,amoxicillin,tetracycline,furazolidone,and gentamicin were 88.66%(219/247),38.46%(95/247),38.06%(94/247),4.05%(10/247),1.21%(3/247),0.40%(1/247),0.40%(1/247),0(0/247),respectively.The dual resistance rate was 38.46%(95/247),with the highest combination resistance observed in clarithromycin + metronidazole(18.62%,46/247),followed by metronidazole + levofloxacin(17.00%,42/247).The multi-drug resistance rate was 19.84%(49/247).There were no significant differences in dual resistance rates(P>0.05)or multiple resistance rates(P>0.05)between different age groups and genders.Conclusions The Hp strains isolated in Shenzhen exhibited relatively higher resistance rates to metronidazole,clarithromycin,and levofloxacin,with substantial dual and multi-drug resistance.
目的 探讨妊娠期糖尿病(GDM)患者载脂蛋白B(Apo-B)、载脂蛋白A1(Apo-A1)水平在分娩巨大儿中的预测价值。方法 选取2023年1月—2024年1月在珠海市第五人民医院建档并进行孕检、分娩的85例GDM患者,按照分娩的新生儿体质量情况分为分娩正常组55例(新生儿体质量<4 000 g)和分娩异常组30例(新生儿体质量≥4 000 g)。比较两组孕妇一般资料及孕早期的Apo-B、Apo-A1、Apo-B/Apo-A1比值,采用受试者操作特征(ROC)曲线分析Apo-B、Apo-A1、Apo-B/Apo-A1对GDM患者分娩巨大儿的预测价值。结果 分娩异常组Apo-B水平、Apo_B/Apo_A1比值(1.05±0.15)g/L、(0.81±0.23)]高于分娩正常组(0.95±0.12)g/L、(0.65±0.18)](t分别为3.357、3.544,P<0.05);Apo-A1水平[(1.29±0.26)g/L]低于分娩正常组[(1.47±0.23)g/L](t=3.292,P<0.05);ROC曲线显示,Apo-B、Apo-A1水平及Apo-B/Apo-A1比值预测GDM患者分娩巨大儿的曲线下面积(AUC)分别为0.705、0.660、0.709,灵敏度分别为63.33%、63.33%、66.67%,特异度分别为72.73%、74.55%、76.36%,其中Apo-B/Apo-A1比值预测效能最高(P<0.05)。结论 GDM患者分娩巨大儿与孕早期Apo-B升高、Apo-A1水平降低密切相关,监测患者孕早期的Apo-B、Apo-A1水平及Apo-B/Apo-A1比值有助于临床对分娩巨大儿进行预测。
Objective To explore the predictive value of apolipoprotein B(Apo-B)and apolipoprotein A1(Apo-A1)levels on delivery of macrosomia in patients with gestational diabetes mellitus(GDM).Methods From January 2023 to January 2024,85 patients with GDM who were filed in the hospital and received pregnancy examination and delivery were selected.According to the neonatal body mass,the patients were divided into 55 cases in normal delivery group(newborn birth weight <4 000 g)and 30 cases in abnormal delivery group( newborn birth weight ≥4 000 g).The general data and levels of Apo-B,Apo-A1 and Apo-B/Apo-A1 in early pregnancy were compared between the two groups.Receiver operating characteristic(ROC)curve was used to analyze the predictive value of Apo-B,Apo-A1 and Apo-B/Apo-A1 on delivery of macrosomia in GDM patients.Results The Apo-B and Apo-B/Apo-A1 in abnormal delivery group were(1.05±0.15)g/L and(0.81±0.23),which were higher than(0.95±0.12)g/L and(0.65±0.18)in normal delivery group(t=3.357,3.544,P<0.05).While the level of Apo-A1 in abnormal delivery group,(1.29±0.26)g/L,was lower than(1.47±0.23)g/L in normal delivery group(t=3.292,P<0.05).ROC curve showed that the areas under the curve(AUC)of Apo-B,Apo-A1 and Apo-B/Apo-A1 in predicting macrosomia in GDM patients were 0.705,0.660 and 0.709,and the sensitivities were 63.33%,63.33% and 66.67%,and the specificities were 72.73%,74.55% and 76.36%,respectively.Apo-B/Apo-A1 had the highest predictive efficiency(P<0.05).Conclusions The delivery of macrosomia in GDM patients is closely related to the increase of Apo-B and the decrease of Apo-A1 in early pregnancy.Monitoring Apo-B,Apo-A1 and Apo-B/Apo-A1 in early pregnancy is helpful to predict the delivery of macrosomia.
目的 探讨脓毒性休克患者肿瘤坏死因子相关受体6 (TRAF6)、胆碱酯酶(ChE)及急性生理学和慢性健康状况评价Ⅱ(APACHE Ⅱ)对预后不良的预测价值。方法 回顾分析2023年2月—2024年3月于某院ICU病区收治的226例脓毒性休克患者的临床资料,基于患者预后情况分为预后良好组(n=151)以及预后不良组(n=75)。回顾226例脓毒性休克患者入院时及治疗后的TRAF6、ChE表达变化,并记录患者APACHEⅡ评分和序贯器官功能衰竭评估(SOFA)评分动态变化;比较并分析两组患者详尽的临床资料,探讨TRAF6、ChE联合APACHE Ⅱ评分之间的关联性以及上述指标对脓毒性休克患者预后情况的临床评估价值。采用Logistic回归来分析对脓毒性休克患者生存状况产生影响的潜在因素。结果 多因素Logistic回归分析,年龄、APACHE Ⅱ评分、SOFA评分、机械通气时间、TRAF6与ChE表达水平均是影响患者预后的独立危险因素(P<0.05);受试者操作特征曲线分析显示,年龄、APACHE Ⅱ评分、机械通气时间、SOFA评分、TRAF6、ChE表达水平联合预测脓毒性休克患者预后不良的曲线下面积为0.925,高于单独检测的0.689、0.783、0.794、0.781、0.708、0.827。结论 临床需要及时识别高龄、长时间机械通气时间、高APACHE Ⅱ与SOFA评分、高TRAF6和ChE表达水平的高风险患者,TRAF6、ChE表达水平、SOFA评分、APACHE Ⅱ评分可作为评估脓毒性休克患者预后情况的临床指标,联合应用能进一步提升临床价值。
Objective To explore the predictive value of tumor necrosis factor receptor associated factor 6(TRAF6),cholinesterase(ChE)and Acute Physiology and Chronic Health Evaluation II scove(APACHE II)for adverse prognosis in patients with septic shock.Methods The clinical data of 226 patients with septic shock admitted to the Intensive Care Unit(ICU) of a hospital from February 2023 to March 2024 were retrospectively analyzed,and the patients were divided into a good prognosis group(n=151)and an adverse prognosis group(n=75)based on their prognosis.The expression of TRAF6 and ChE in 226 patients with septic shock was reviewed at admission and after treatment,while the dynamic changes of APACHE II score and Sequential Organ Failure Assessment(SOFA)score were recorded.Detailed clinical data of the two groups were compared and analyzed to explore the correlation between TRAF6,ChE,APACHE II scores and the clinical evaluation value of the above indexes in the prognosis of patients with septic shock.Logistic regression was used to analyze the potential factors affecting the survival of septic shock patients.Results Multiple Logistic regression analysis revealed that age,APACHE II score,SOFA score,mechanical ventilation time,TRAF6 and ChE expression levels were independent risk factors for prognosis(P<0.05).Receiver Operating Characteristic(ROC)curve analysis showed that the area under curve(AUC)was 0.925,which was higher than single index prediction(0.689,0.783,0.794,0.781,0.708 and 0.827).Conclusions High-risk patients with advanced age,prolonged mechanical ventilation,high APACHE II and SOFA scores,and high TRAF6 and ChE expression levels need to be identified in time.TRAF6,ChE expression levels,SOFA scores,and APACHE II scores can be used as clinical indicators to evaluate the prognosis of septic shock patients.The combined application of those four indicators can further improve the clinical value.
目的 通过对压疮不同治疗方式的分析,探讨疾病诊断相关分组(DRG)组合的特征,提高核心疾病诊断相关组(ADRG)的入组率和提升相对权重值,从而提升医疗服务效率和水平。方法 使用医院DRGs分析评价系统以及EXCEL软件筛选出2023—2024年广州市第一人民医院主要诊断压疮疾病病例,分析ADRG组合的特征。结果 根据压疮疾病不同治疗方式,主要诊断为压疮(L89)的176病例进入相对的外科治疗组和内科治疗组,ADRG组分别为JD1组合、JJ1组合、JV1组合。JJ1组合治疗方案以创面封闭式负压引流为主;JD1组合的外科治疗方式均是以皮肤和皮下坏死组织的切除清创术+创面封闭式负压引流术(VSD)的手术治疗方案。JD13组、JD15组比JJ13组、JJ15组,相对权重分别高2.35和1.48。26例患者的住院时间均超过60 d,导致进入了QY组合。结论 利用好DRGs工具能有效地提高压疮的入组率,结合精细化的首页质量管理,提升DRGs的组合权重值及医疗服务效率和水平。
Objective To analyze different treatment methods for pressure ulcers and explore the characteristics of Diagnosis-Related Groups(DRGs)to improve the admission rate of Adjacent DRGs(ADRGs)and enhance the relative weight value,thereby improving the efficiency and level of medical services.Methods Using the DRGs management system and EXCEL software,cases of pressure ulcer disease from Class A tertiary hospital in Guangzhou from 2023 to 2024 were selected,with pressure ulcers as the primary diagnosis,and analyzed the characteristics of ADRG combinations.Results Based on different treatment methods for pressure ulcers,176 cases primarily diagnosed with pressure ulcers(L89)were categorized into relative surgical and medical treatment groups,with ADRG groups being JD1,JJ1,and JV1 combinations.The JJ1 group’s treatment plan primarily focused on closed wound negative pressure drainage,the surgical treatment method for JD1 group involved skin and subcutaneous necrotic tissue excision and debridement surgery combined with closed wound negative pressure drainage(VSD).The relative weights of JD13 and JD15 groups were 2.35 and 1.48,higher than those of JJ13 and JJ15 groups.Twenty-six cases had an average hospital stay exceeding 60 days,leading to their categorization into the QY group.Conclusions Utilizing the DRG tool effectively improves the admission rate for pressure ulcer diseases.By combining it with refined quality management on the first page of medical records,the combination weight value of DRGs and the efficiency and level of medical services can be enhanced.
目的 探讨超声引导下腹横肌平面阻滞(TAP)联合无阿片药全身麻醉(全麻)在腹腔镜子宫全切术中的应用效果。方法 选取武威市凉州医院2021年5月—2023年5月收治的60例择期行腹腔镜子宫全切术患者展开前瞻性研究,应用抽签法将其分为观察组与对照组,各30例。对照组患者实施常规阿片类药物全麻,观察组采用TAP联合无阿片药全身麻醉。对比两组患者入室后(T0)、切皮时(T1)、手术10 min后(T2)和手术结束即刻(T3)生命体征变化,麻醉后监测治疗室(PACU)恢复情况,术后1、4、8、12、24、48 h疼痛程度,最后对比其48 h内不良反应发生率。结果 两组T0、T1、T2、T3时间血氧饱和度(SpO2),T0、T3时间平均动脉压(MAP)、心率水平无明显变化,两组对比差异无统计学意义(P>0.05),T1、T2时间对照组MAP、心率升高,观察组T1、T2的MAP、心率均低于对照组(P<0.05);观察组PACU停留时间、首次肛门排气时间明显低于对照组(P<0.05);观察组术后1、4、8、12、24、48 h活动时视觉模量表(VAS)评分与静息时VAS评分低于对照组(P<0.05);观察组术后48 h内不良反应发生率比对照组更低(P<0.05)。结论 针对腹腔镜子宫全切术患者采取超声引下TAP联合无阿片药全麻可稳定患者术中生命体征,缩短患者术后恢复时间,减轻疼痛程度,且可降低术后48 h内不良反应发生率。
Objective To explore the application effect of ultrasound-guided transverse abdominis plane(TAP)block combined with opioid-free general anesthesia in laparoscopic total hysterectomy.Methods A prospective study was conducted in 60 patients who underwent selective laparoscopic total hysterectomy in Wuwei Liangzhou Hospital from May 2021 to May 2023.They were divided into a observation group and a control group using a lottery method,30 cases in each group.The control group received routine opioid general anaesthesia,while the observation group received TAP in combination with opioid-free general anaesthesia.Comparing the changes of vital signs after invasion(T0),skin cutting(T1),10 min after operating(T2),the end of surgery(T3),and condition in the post-anesthesia care unit(PACU)after anesthesia,the pain degree at 1 h,4 h,8 h,12 h,24 h and 48 h after surgery,and the incidence of adverse reactions within 48 h.Results There were no significant changes in blood SpO2,mean arterial pressure(MAP)and heart rate at T0,T1,T2 and T3 in both groups,and no significant difference between the two groups(P>0.05).MAP and heart rate increased in the control group at T1 and T2,while those in the observation group were lower than the control group(P<0.05).The observation group had significantly shorter PACU time and first anal exhaust time than the control group(P<0.05).VAS scores at 1 h,4 h,8 h,12 h,24 h and 48 h after surgery and VAS score at rest in the observation group were lower than in the control group(P<0.05).The incidence of adverse reactions within 48 h after surgery was lower in the observation group than in the control group(P<0.05).Conclusions Ultrasound guided TAP combined with opioid-free general anesthesia can stabilize intraoperative vital signs,shorten postoperative recovery time,alleviate postoperative pain,and reduce the incidence of anesthesia related adverse reactions within 48 hours for patients undergoing laparoscopic total hysterectomy.
目的 探讨肺癌伴癌性疼痛患者心理僵化现状及其影响因素,为临床制定改善患者心理僵化的针对性干预措施以及提升患者生活质量提供参考依据。方法 采用便利抽样法,选取2023年10月—12月期间焦作市某三级甲等医院收治的肺癌伴癌性疼痛患者为研究对象,采用一般资料调查问卷、疼痛心理僵化量表(PIPS)、简易疾病感知问卷(BIPQ)、家庭功能问卷(APGAR)进行调查,采用Pearson相关性分析肺癌伴癌性疼痛患者心理僵化与疾病感知、家庭功能的关系。采用多元线性回归分析肺癌伴癌性疼痛患者心理僵化的影响因素。结果 本次研究共发放问卷152份,回收有效问卷150份,有效回收率为98.68%。150例肺癌伴癌性疼痛患者心理僵化量表总分为(61.66±2.85)分,回避型经验维度得分为(45.52±1.97)分,认知融合维度得分为(19.74±1.59)分。不同文化程度、家庭人均月收入、疼痛程度的肺癌伴癌性疼痛患者心理僵化得分比较,差异有统计学意义(P<0.05)。Pearson相关性分析结果显示:肺癌伴癌性疼痛患者心理僵化总分、经验性回避维度得分、认知融合维度得分与疾病感知得分均呈正相关关系(P<0.001),与家庭功能得分均呈负相关关系(P<0.001)。多元线性回归结果显示:文化程度、家庭人均月收入、疾病感知、家庭功能是肺癌伴癌性疼痛患者心理僵化的影响因素(P<0.05),可解释肺癌伴癌性疼痛患者心理僵化43.9%的变异度。结论 肺癌伴癌性疼痛患者心理僵化处于较高水平,且受到文化程度、家庭人均月收入、疾病感知和家庭功能的影响,临床医护人员可从疾病感知、家庭支持等角度出发,采用认知干预、同伴支持等方法,加强对患者的健康教育,以缓解其对疾病的负性认知,从而缓解心理僵化,促进身心健康恢复。
Objective To explore the status and influencing factors of psychological rigidity in patients with lung cancer and cancer pain,and to provide reference for clinical development of targeted interventions to improve patients’psychological rigidity andquality of life.Methods The convenience sampling method was used to select patients with lung cancer and cancer pain who were admitted to a tertiary hospital in Jiaozuo City from October to December 2023 as the research object.The general data questionnaire,Psychological Inflexibility in Pain Scale(PIPS),Brief Illness Perception Questionnaire(BIPQ),and family function questionnaire(APGAR)were used to investigate.Pearson correlation analysis was used to analyze the relationship between psychological rigidity and disease perception and family function in patients with lung cancer and cancer pain.Multivariate linear regression was used to analyze the influencing factors of psychological rigidity in patients with lung cancer and cancer pain.Results A total of 152 questionnaires were distributed in this study,and 150 valid questionnaires were recovered,with an effective recovery rate of 98.68 %.The total score of PIPS of 150 patients with lung cancer and cancer pain was(61.66±2.85),the score of avoidance experience dimension was(45.52±1.97),and the score of cognitive fusion dimension was(19.74±1.59).There were statistically significant differences in the scores of psychological rigidity among lung cancer patients with cancer pain with different educational levels,family per capita monthly income,and pain degree(P<0.05).The results of Pearson correlation analysis showed that the total score of PIPS,the score of empirical avoidance dimension and the score of cognitive fusion dimension were positively correlated with the score of disease perception(P<0.001),and negatively correlated with the score of family function(P<0.001).The results of multiple linear regression showed that education level,family per capita monthly income,disease perception and family function were the influencing factors of psychological rigidity in patients with lung cancer and cancer pain(P<0.05 ),which could explain 43.9 % of the variation of psychological rigidity in patients with lung cancer and cancer pain.Conclusions The psychological rigidity of lung cancer patients with cancer pain is at a high level,and is affected by education level,family per capita monthly income,disease perception and family function.Clinical medical staff can use cognitive intervention and peer support from the perspective of disease perception and family support to strengthen the health education of patients,so as to alleviate their negative cognition of the disease,to alleviate the psychological rigidity and promote the recovery of physical and mental health.
目的 探讨断指再植患者采用微波理疗联合康复训练的影响。方法 回顾性选取2022年1月—2023年12月于福州市第二总医院进行断指再植的患者,采用康复训练的50例患者纳入对照组,采用微波理疗联合康复训练的51例患者纳入观察组,对比两组干预1个月后的毛细血管反应情况、感知恢复情况、疼痛评分、手指功能及日常生活能力情况。结果 干预1个月后, 观察组患指的温度[(28.43±5.86)℃ vs (26.15±5.39)℃,t=2.025,P<0.001]、毛细血管反应[(9.76±2.63)cm/s vs(7.36±2.23)cm/s,t=4.922,P=0.046,]高于对照组(P<0.05);观察组的英国医学研究委员会感觉评分[(15.79±3.75)分 vs(11.88±3.13)分,t=5.660,P<0.001]高于对照组;观察组第2周[(3.72±0.88)分 vs(4.39±0.92)分,t=3.721,P<0.001]、4周后[(2.67±0.32)分 vs(3.03±0.52)分,t=4.169,P=0.001]的视觉模拟量表(VAS)评分低于对照组(P<0.05);观察组的密歇根手功能量表(MHQ)评分[(61.05±10.68)分 vs(52.58±10.21)分,t=4.054,P<0.001]高于对照组(P<0.05);观察组的生活质量综合评定表(GQLI-74)评分[(320.16±55.25)分 vs(270.85±50.06)分,t=4.677,P<0.001]高于对照组(P<0.05);观察组的Barthel指数[(75.71±12.84)分 vs(68.58±12.23)分,t=2.843,P=0.005]高于对照组(P<0.05)。结论 微波理疗联合康复训练能够提高断指再植患者的手指功能,减轻患者疼痛,改善日常生活质量。
Objective To explore the effect of microwave physiotherapy combined with rehabilitation training on finger function and daily living ability of patients with severed finger replantation.Methods Patients who underwent replantation of severed fingers in our hospital from January 2022 to December 2023 were selected retrospectively.Fifty patients who received rehabilitation training were included in the control group,51 patients who were intervened by microwave physiotherapy combined with rehabilitation training were included in the observation group.The blood circulation,sensory recovery,pain score,finger function and daily living ability of the two groups were compared.Results The temperature([28.43±5.86]℃ vs [26.15±5.39]℃,t=2.025,P<0.001) and capillary reaction([9.76±2.63]cm/s vs [7.36±2.23]cm/s,t=4.922,P=0.046) of the affected fingers in the observation group were higher(P<0.05).The sensory score([15.79±3.75] vs [11.88±3.13],t=5.660,P<0.001)of the observation group was higher than that of the control group(P<0.05).The visual analogue scale(VAS)scores of the observation group at the second week([3.72±0.88] vs [4.39±0.92],t=3.721,P<0.001) and four weeks later([2.67±0.32]vs [3.03±0.52],t=4.169,P=0.001)were lower than those of the control group(P<0.05).The score of Michigan Hand Outcome Questionnair(MHQ)([61.05±10.68] vs [52.58±10.21],t=4.054,P<0.001) in the observation group was higher(P<0.05).The GQLI-74 score([320.16±55.25] vs [270.85±50.06]) and Barthel index([75.71±12.84] vs[68.58±12.23],t=2.843,P=0.005)in the observation group were higher(P<0.05).Conclusions Microwave physiotherapy combined with rehabilitation training can improve the finger function,relieve the pain and improve the quality of daily life of patients with severed fingers.
目的 分析广州番禺地区鹦鹉热衣原体肺炎患者临床表现、实验室及胸部CT特征、并发症以及治疗方案,为其临床诊治提供参考。方法 回顾性分析2022年1月—2024年7月在广州市番禺区何贤纪念医院通过二代测序技术确诊的10例鹦鹉热感染患者的临床资料。结果 5例(5/10)患者有明确的鸟类或禽类接触史,8例(8/10)患者以发热为首发症状,发热(10/10)、咳嗽、咳痰(10/10)、呼吸困难(7/10)、相对缓脉(8/10)是主要临床表现。患者白细胞计数通常正常或轻微升高;多数患者存在有不同程度的电解质紊乱(10/10)及肝功能损伤(8/10)、乳酸脱氢酶升高(8/10),白蛋白显著降低(8/10)和C反应蛋白显著升高(10/10)。最常见的胸部CT异常为多肺叶受累的斑片状或片状实变,而重症患者多合并双侧胸腔积液。大多数患者经四环素或喹诺酮类单用,或者四环素联用β-内酰胺类抗菌药物治疗,预后良好。结论 有鸟类或禽类接触史、以发热为首发或主要症状、存在相对缓脉、白细胞计数升高不明显等临床特征可有助于区分鹦鹉热衣原体肺炎与其他传统细菌性肺炎,但这并不能确诊。二代测序技术是确诊鹦鹉热衣原体感染的很好方法,可以缩短诊断延误时间并改善患者预后。
Objective To describe the clinical,laboratory and chest CT characteristics as well as the complications and treatments of Chlamydia psittaci pneumonia patients in Panyu district of Guangzhou,to provide reference for clinical diagnosis and treatment.Methods A retrospective study was conducted on the clinical characteristics of Chlamydia psittaci pneumonia patients who were diagnosed by next-generation sequencing in Panyu Hexian Memorial Hospital of Guangzhou form January 2022 to July 2024.Results Half patients had a definite history of bird or poultry exposure.Fever(100%),cough,sputum(100%),dyspnea(70%),relative bradycardia(80%)were the main clinical presentation.The total white cell counts were usually normal or slightly increased.Most patients had electrolyte disturbance(100%),liver function impairment(80%),lactic dehydrogenase increased(80%),albumin decreased(80%)and C reactive protein increased remarkably(100%).The most common chest CT abnormality was patchy or flaky hyper densities and consolidation,bilateral pleural effusion was common in severe patients.All patient exhibited good recovery after being treated with tetracycline or quinolone alone,or tetracycline in combination with other antibiotics.Conclusions These characteristics may help distinguish Chlamydia psittaci pneumonia from other traditional bacterial pneumonia,but they are not definitive.Next-generation sequencing may be a promising approach to confirm Chlamydia psittaciinfection,which can shorten the diagnostic delay time and improve the prognosis of patients.
目的 调查江西省南昌市东湖区孕妇2022—2024年碘营养状况与盐碘监测情况,为区域干预提供依据。方法 将江西省南昌市东湖区划分为东、南、西、北、中5个片区,每个片区随机抽取一个街道(管理处),于每年5月份随机抽取各街道(管理处)20名孕妇,每年共抽取100名孕妇,3年共计300名孕妇,采集其尿液样本和家中食用盐样本检测碘含量,以统计学方法进行分析。结果 3年来孕妇家庭食用盐碘含量中位数为23.02 mg/kg,碘盐覆盖率为98.67%,碘盐合格率为95.33%,3年的食用盐碘含量比较差异有统计学意义(H=38.545,P<0.05)。孕妇的尿碘水平中位数为115.15 μg/mL,3年来孕妇的尿碘水平中位数均低于150 μg/mL,有62.67%的孕妇碘缺乏,3年间的尿碘水平比较差异有统计学意义(H=9.392,P<0.05),其中2024年的尿碘水平中位数为140.00 μg/mL,校正后高于2022年(Z=2.693,P<0.0167)和2023年(Z=2.590,P<0.0167)。Spearman相关性分析结果显示孕妇尿碘水平与盐碘含量及碘盐质量均无相关性(均P>0.05),孕妇碘营养状况与盐碘含量及碘盐质量均无相关性(均P>0.05),孕妇尿碘水平与碘营养状况正相关(rs=0.857,P<0.05),盐碘含量与碘盐质量正相关(rs=0.314,P<0.05)。结论 江西省南昌市东湖区2024年孕妇碘缺乏有所改善,但整体形势严峻,超半数的孕妇碘缺乏,食用碘盐基本符合国家消除碘缺乏病标准,但仍需改进。卫生部门要强化孕妇碘营养监测,向孕妇科普碘缺乏病知识,增强补碘意识,促其科学补碘。盐业监管部门需加大监管,严控碘盐质量,确保东湖区居民食盐合格。
Objective To investigate the iodine nutrition status of pregnant women and iodined salt monitoring in Donghu District,Nanchang City,Jiangxi Province from 2022 to 2024,and provide a basis for regional intervention.Methods Donghu District was divided into five areas:East,South,West,North,and Central.A street(management office)was randomly selected from each area,and 20 pregnant women were randomly selected from each street(management office)in May each year.A total of 100 pregnant women were selected each year,for a total of 300 pregnant women over three years.Urine samples and household salt samples were collected to detect iodine content,and statistical analysis was conducted.Results Over the past three years,the median iodine content in the cooking salt consumed by pregnant women’s families was 23.02 mg/kg,the iodized salt coverage rate was 98.67%,and the iodized salt qualification rate was 95.33%.There were differences in the iodine content of cooking salt in the three years(H=38.545,P<0.05).The median urinary iodine level of pregnant women was 115.15 μg/mL.In the past three years,the median urinary iodine levels of pregnant women were all lower than 150 μg/ml,and 62.67% of pregnant women were iodine-deficient.There were differences in the urinary iodine levels in the three years(H=9.392,P<0.05).Among them,the median urinary iodine level in 2024 was 140.00 μg/mL,which was significantly higher than that in 2022(Z=2.693,P<0.0167)and 2023(Z=2.590,P<0.0167)after correcting the significance level.Spearman correlation analysis results showed that there was no correlation between the urinary iodine level of pregnant women with the iodine content and quality of iodized salt(all P>0.05),and there was no correlation between the iodine nutritional status of pregnant women with the iodine content and quality of iodized salt(all P>0.05).The urinary iodine level in pregnant women is positively correlated with their iodine nutritional status(rs=0.857,P<0.05),and the iodine content in salt is positively correlated with the quality of iodized salt(rs=0.314,P<0.05).Conclusions In 2024,the iodine deficiency among pregnant women in Donghu District,Nanchang City,Jiangxi Province was improved,but the overall situation is still severe.More than half of pregnant women were iodine-deficient.The consumption of iodized salt basically met the national standards for eliminating iodine deficiency disorders,but still needed to be improved.The health department should strengthen the monitoring of iodine nutrition among pregnant women,popularize knowledge about iodine deficiency disorders to pregnant women,enhance their awareness of iodine supplementation,and promote their scientific iodine supplementation.The salt industry supervision department needs to strengthen supervision,strictly control the quality of iodized salt,and ensure that the cooking salt of residents in Donghu District is qualified.