目的 探讨广州市公职人员中眼睑黄色瘤（XP）患病情况与生化检验指标异常的相关性。方法 从2018年来广州市干部和人才健康管理中心体检的公职人员中选取1 090例，其中筛选患XP人员545例，作为病例组，依性别、年龄分层随机抽取的未患XP的人员作为对照组，测定空腹血糖、血脂、甲状腺功能等生化指标，采用回顾性病例对照研究的方式，比较两组相关指标水平。P＜0.05为差异有统计学意义。结果 XP的患病率为0.94%（男性为0.89%，女性为1.01%）。男性和女性的XP患病率比较差异无统计学意义（χ²=2.142，P=0.143）。两组间体质量、舒张压、血脂等多项指标上的差异具有统计学意义（P＜0.05）。高体质量（OR=1.021，95%CI：1.004~1.038，P=0.017）、高舒张压（OR=1.019，95%CI：1.004~1.035，P=0.011）、低高密度脂蛋白（OR=6.127，95%CI：2.568~14.619，P＜0.001）、高低密度脂蛋白（OR=2.084，95%CI：1.456~2.981，P＜0.001）是患病的危险因素。结论 广州市公职人员中XP的患病率男性和女性接近；高体质量、高舒张压、高密度脂蛋白水平降低、低密度脂蛋白水平升高是患XP的危险因素。

   Objective To investigate the correlation between xanthelasma palpebrarum（XP）and abnormal biochemical indices in healthy individuals in Guangzhou，China．Methods A retrospective case-control study was conducted，selecting 1 090 individuals from a total of 58 053 who underwent health examinations at the Guangzhou Cadre and Talent Health Management Centre in 2018．The case group consisted of 545 individuals diagnosed with XP，while the control group included age- and sex-matched individuals without XP，randomly selected from the same database．Biochemical indices analyzed included fasting blood glucose，blood lipids，liver and kidney function，thyroid indicators，body weight，and blood pressure．Statistical significance was set at P＜0.05．Results The prevalence of XP was 0.94%（0.89% in men and 1.01% in women）．No significant difference was observed in the prevalence of XP between men and women（χ²=2.142，P=0.143）．Similarly，no significant differences were observed in thyroid-stimulating hormone（P=0.937），free triiodothyronine（P=0.216），free thyroxin（P=0.206），or fasting blood glucose levels（P=0.668）between the case and control groups．However，significant differences were noted in body weight，diastolic blood pressure，blood lipid levels，and liver and renal biochemical indicators between the two groups（P＜0.05）．Specifically，higher body weight（OR=1.021，95%CI：1.004–1.038，P=0.017），higher diastolic blood pressure（OR=1.019，95%CI：1.004–1.035，P=0.011），lower high-density lipoprotein（OR=6.127，95%CI：2.568–14.619，P＜0.001），and higher low-density lipoprotein（OR=2.084，95%CI：1.456–2.981，P＜0.001）were identified as risk factors for XP．Conclusions The prevalence of XP did not differ between males and females．However，high body weight，high diastolic blood pressure，low high-density lipoprotein，and high low-density lipoprotein are risk factors for XP．

目的 探讨规范二级预防下老老年人轻型卒中复发的危险因素。方法 收集我院80岁及以上、既往有轻型卒中病史、并进行规范二级预防半年以上的老老年患者的临床资料:一般资料、既往病史及用药情况、入院时血压及基础生化指标、影像学资料、缺血性卒中复发情况。根据有无复发缺血性卒中将患者分为复发组和无复发组两组,分析以上因素在两组间的差异。结果 80例患者中复发缺血性脑卒中共26例,复发率32.5%。统计结果显示,轻型卒中复发组与合并高血压病、入院时收缩压、D二聚体水平呈正相关,其相关系数分别为0.265(P=0.018)、0.232(P=0.038)和0.222(P=0.048)。复发组收缩压升高比例高于无复发组(χ²=6.919,P=0.031)。非条件Logistic多因素分析显示:合并高血压病[OR 95%CI=(1.162,10.230)]、收缩压升高[OR 95%CI=(0.997,68.840)]与轻型缺血性卒中复发相关。结论 合并高血压病、收缩压升高是老老年人轻型卒中规范二级预防下复发独立危险因素。

Objective To analyze the recurrence risk factors of aged patients with minor ischemic stroke under standardized secondary prevention. Methods Patients over 80 years old and with minor ischemic stroke history were enrolled, and the following data were collected: demographic characteristics, medical history, current medicine, blood test, imaging findings and recurrence of ischemic strokes. Patients were divided into two groups: the recurrence group and the non-recurrence group. Chi-square test,logistic regression models were performed to assess correlations between baseline variables and recurrence of minor stroke events. Results In our study, 26 patients had recurrent minor ischemic stroke(32.5%). The prevalence of recurrence of minor stroke was positively correlated with hypertension(CI 0.265, P 0.018), SBP(CI 0.232,P 0.038), d-2-dimer(CI 0.232,P 0.048). Patients in recurrence group are more likely to presented with SBP elevation compared to non-recurrence group(χ²=6.919, P=0.031). Unconditional logistic regression analysis showed that hypertension, especially high SBP significantly related to minor ischemic stroke recurrence. Conclusion Hypertension,especially elevated SBP, were considered as an independent risk factors for aged old patients with minor ischemic stroke who received standardized secondary prevention.