广州地区鲍曼不动杆菌的多位点序列分型及流行克隆

来源期刊：广州医药 | 20-25 发布时间：2022-04-12 收稿时间：2025/11/13 18:25:50 阅读量：103

作者：: 郭伟鸿,

潘楚芝,

黄慕超,

方昌全,

郭鹏豪,

陈惠玲,

赵子文,

李裕军,

关键词：: 鲍曼不动杆菌多位点序列分型广州地区; Acinetobacter baumannii" style="padding-right:10px">Acinetobacter baumannii')">Acinetobacter baumanniimultilocus sequence typing Guangzhou area

DOI：: 10.3969/j.issn.1000-8535.2022.01.004

收稿时间：: 2021-08-19
修订日期：
接收日期：
引用总数：: 5

目的本研究对广州地区5家教学医院的鲍曼不动杆菌进行分子流行病学分析。方法 5家教学医院共采集138株鲍曼不动杆菌,利用多位点序列分型(multilocus sequence typing,MLST)及eBURST算法评价菌株之间的遗传关系。结果 MLST将138株鲍曼不动杆菌分为8个已有序列类型(STs),分别为ST195、ST208、ST457、ST136、ST254、ST548、ST445和ST53,还发现17个新STs。其中ST195的数量最多,占所有分离株的35.5%(49/138),其次为ST208,占所有分离株的21.0%(29/138)。eBURST算法分析显示以ST195为预测祖先型的克隆复合体(clonal complex, CC) 195在医院环境中广泛传播。结论鲍曼不动杆菌CC195是广州地区的流行克隆,各家医疗机构应根据其自身实际制定感染防控策略。

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